Essays on the APS Classic Papers
Celebrating more than 100 years of the APS Journals content

The American Physiological Society is proud to announce that the full historical content of its 14 journals, going back to the very first issues of the American Journal of Physiology in 1898, is now available online. To commemorate this event, we have asked 24 authors to write essays on some of the most significant articles from the body of APS literature.

Introduction to the classic papers commemorating the APS Legacy Project
by Hershel Raff, Dale Benos, and Margaret Reich


View the Classic Articles by Journal

Read the First Issue of Each Journal FREE!

Click on an author or title below to read the commemorative essays:

Adrenal cortex: scalpels, syringes, and separatory funnels
by Susan F. Akana
Berne�s adenosine hypothesis of coronary blood flow control
by Eric O. Feigl
Acute hypoxia and pulmonary vasoconstriction in humans: uncovering the mechanism of the pressor response
by Alfred P. Fishman
Two classic papers in acid-base physiology: contributions of R. F. Pitts, R. S. Alexander, and W. D. Lotspeich
by Gerhard Giebisch
Discovery of the luteinizing hormone of the anterior pituitary gland
by H. Maurice Goodman
The pioneering use of systems analysis to study cardiac output regulation
by John E. Hall
Ca-induced Ca release: lessons regarding cell models
by David R. Harder
The development of clearance methods for measurement of glomerular filtration and tubular reabsorption
by T. H. Hostetter and T.W. Meyer
Nature vs. nurture: can exercise really alter fiber type composition in human skeletal muscle?
by Christopher P. Ingalls
Hypothalamic control of body temperature: insights from the past
by Gary W. Mack
Microvascular permeability, ultra-filtration, and restricted diffusion
by C. C. Michel
Stresses on pulmonary blood vessels
by Wayne Mitzner
The basis for transport across epithelial cells
by Marshall H. Montrose
Comroe's study of aortic chemoreceptors: a path well chosen
by Judith A. Neubauer
The significance of the blood gas analyzer
by Hershel Raff
Discovering the role of the adrenal gland in the control of body function
by David C. Randall
Eugene M. Landis and the physiology of the microcirculation
by E. M. Renkin
Micropuncture: unlocking the secrets of renal function
by Jeff M. Sands
Experimental validation of the countercurrent model of urinary concentration
by James A. Schafer
First electrodes for blood Po2 and Pco2 determination
by John W. Severinghaus
Anterior pituitary hormones: development of a bioassay leading to the discovery of prolactin
by M. Susan Smith
The paper that completely altered our thinking about cerebral blood flow measurement
by Richard J. Traystman
Understanding pulmonary gas exchange: ventilation-perfusion relationships
by John B. West

 

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Index of the Classic Articles:

American Journal of Physiology

Berne RM. Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. Am J Physiol 204: 317-322, 1963.

Cannon WB. The emergency function of the adrenal medulla in pain and the major emotions. Am J Physiol 33: 356-372, 1914.

Cannon WB. Studies on the conditions of activity in endocrine glands. V. The isolated heart as an indicator of adrenal secretion induced by pain, asphyxia and excitement. Am J Physiol 50: 399-432, 1919.

Cannon WB and de la Paz D. Emotional stimulation of adrenal secretion. Am J Physiol 28: 64-70, 1911.

Comroe JH Jr. The location and function of the chemoreceptors of the aorta. Am J Physiol 127: 176-191, 1939.

Fenn WO, Rahn H, and Otis AB. A theoretical study of the composition of the alveolar air at altitude. Am J Physiol 146: 637-653, 1946.

Fevold HL, Hisaw FL, Leonard SL. The gonad stimulating and the luteinizing hormones of the anterior lobe of the hypophysis. Am J Physiol 97: 291-301, 1931.

Gottschalk CW, Lassiter WE, Mylle M, Ullrich KJ, Schmidt-Nielsen B, O'Dell R, and Pehling G. Micropuncture study of composition of loop of Henle fluid in desert rodents. Am J Physiol 204: 532-535, 1963.

Gottschalk CW and Mylle M. Micropuncture study of the mammalian urinary concentrating mechanism: evidence for the countercurrent hypothesis. Am J Physiol 196: 927-936, 1959.

Guyton AC, Lindsey AW, and Kaufmann BN. Effect of mean circulatory filling pressure and other peripheral circulatory factors on cardiac output. Am J Physiol 180: 463-468, 1955.

Hammel HT, Hardy JD, and Fusco MM. Thermoregulatory responses to hypothalamic cooling in unanesthetized dogs. Am J Physiol 198: 481-486, 1960.

Hellstrom B and Hammel HT. Some characteristics of temperature regulation in the unanesthetized dog. Am J Physiol 213: 547-556, 1967.

Houssay BA and Lewis JT. The relative importance to life of cortex and medulla of the adrenal glands. Am J Physiol 64: 512-521, 1923.

Ingraham RC and Visscher MB. Further studies on intestinal absorption with the performance of osmotic work. Am J Physiol 121: 771-785, 1938.

Jolliffe N, Shannon JA, and Smith HW. The excretion of urine in the dog. III. The use of non-metabolized sugars in the measurement of the glomerular filtrate. Am J Physiol 100: 301-312, 1932.

Kety SS, and Schmidt CF. The determination of cerebral blood flow in man by the use of nitrous oxide in low concentrations. Am J Physiol 143: 53-66, 1945.

Landis EM. The capillary pressure in frog mesentery as determined by micro-injection methods. Am J Physiol 75: 548-570, 1926.

Landis EM. Micro-injection studies of capillary permeability. II. The relation between capillary pressure and the rate at which fluid passes through the walls of single capillaries. Am J Physiol 82: 217-238, 1927.

Marine D and Baumann EJ. Duration of life after suprarenalectomy in cats and attempts to prolong it by injections of solutions containing sodium salts, glucose and glycerol. Am J Physiology 81: 86-100, 1927.

Motley, HL, Cournand, A, Werko, L, Himmelstein, A, Dresdale, D. The influence of short periods of induced acute anoxia upon pulmonary artery pressures in man. Am J Physiol 150: 315-320, 1947.

Pappenheimer JR and Soto-Rivera A. Effective osmotic pressure of the plasma proteins and other quantities associated with the capillary circulation in the hind limbs of cats and dogs. Am J Physiol 152: 471-491, 1948

Pappenheimer JR, Renkin EM and Borrero LM. Filtration, diffusion and molecular sieving through peripheral capillary membranes: A contribution to the pore theory of capillary permeability. Am J Physiol 167: 13-46, 1951.

Pitts RF and Alexander, RS. The nature of the renal tubular mechanism for acidifying the urine. Am J Physiol 144: 239-254, 1945.

Pitts RF and Lotspeich WD. Bicarbonate and the renal regulation of acid base balance. Am J Physiol 147:138-154, 1946.

Rahn H. A concept of mean alveolar air and the ventilation-bloodflow relationships during pulmonary gas exchange. Am J Physiol 158: 21-30, 1949.

Richards AN and Walker AM. Methods of collecting fluid from known regions of the renal tubules of Amphibia and of perfusing the lumen of a single tubule. Am J Physiol 118: 111-120, 1936.

Riddle O, Bates RW, and Dykshorn SW. The preparation, identification and assay of prolactin�a hormone of the anterior pituitary. Am J Physiol 105: 191-216, 1933.

Shannon JA. The excretion of inulin by the dog. Am J Physiol 112: 405-413, 1935.

Shannon JA and Fisher S. The renal tubular reabsorption of glucose in the normal dog. Am J Physiol 122: 765-774, 1938.

Shannon JA, Farber S, and Troast L. The measurement of glucose Tm in the normal dog. Am J Physiol 133: 752-761, 1941.

Swingle WW and Pfiffner JJ. Studies on the adrenal cortex. I. The effect of a lipid fraction upon the life-span of adrenalectomized cats. Am J Physiol 96: 153-163, 1931.

Ullrich KJ, Schmidt-Nielsen B, O'Dell R, Pehling G, Gottschalk CW, Lassiter WE, and Mylle M. Micropuncture study of composition of proximal and distal tubular fluid in rat kidney. Am J Physiol 204: 527-531, 1963.

Visscher MB, Fetcher ES Jr, Carr CW, Gregor HP, Bushey MS, and Barker DE. Isotopic tracer studies on the movement of water and ions between intestinal lumen and blood. Am J Physiol 142: 550-575, 1944.

Walker AM, Bott PA, Oliver J, and MacDowell MC. The collection and analysis of fluid from single nephrons of the mammalian kidney. Am J Physiol 134: 580-595, 1941.

Walker AM and Hudson CL. The reabsorption of glucose from the renal tubule in Amphibia and the action of phlorhizin upon it. Am J Physiol 118: 130-143, 1936.

Walker AM and Oliver J. Methods for the collection of fluid from single glomeruli and tubules of the mammalian kidney. Am J Physiol 134: 562-579, 19414.

Wearn JT and Richards AN. Observations on the composition of glomerular urine, with particular reference to the problem of reabsorption in the renal tubules. Am J Physiol 71: 209-227, 1924.

American Journal of Physiology - Cell Physiology

Fabiato A. Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am J Physiol Cell Physiol 245: C1-C14, 1983.

Journal of Applied Physiology

Gollnick PD, Armstrong RB, Saubert CW IV, Piehl K, and Saltin B. Enzyme activity and fiber composition in skeletal muscle of untrained and trained men. J Appl Physiol 33: 312-319, 1972.

Gollnick PD, Armstrong RB, Saltin B, Saubert CW IV, Sembrowich WL, and Shepherd RE. Effect of training on enzyme activity and fiber composition of human skeletal muscle. J Appl Physiol 34: 107-111, 1973.

Hammel HT, Jackson DC, Stolwijk JAJ, Hardy JD, and Str�mme SB. Temperature regulation by hypothalamic proportional control with an adjustable set point. J Appl Physiol 18: 1146-1154, 1963.

Howell JBL, Permutt S, Proctor DF, and Riley RL. Effect of inflation of the lung on different parts of pulmonary vascular bed. J Appl Physiol 16: 71-76, 1961.

Permutt S, Howell JBL, Proctor DF, and Riley RL. Effect of lung inflation on static pressure-volume characteristics of pulmonary vessels. J Appl Physiol 16: 64-70, 1961.

Riley RL and Cournand A. "Ideal" alveolar air and the analysis of ventilation-perfusion relationships in the lungs. J Appl Physiol 1: 825-847, 1949.

Riley RL and Cournand A. Analysis of factors affecting partial pressures of oxygen and carbon dioxide in gas and blood of lungs: theory. J Appl Physiol 4: 77-101, 1951.

Severinghaus, JW, and Bradley, AF. Electrodes for blood Po2 and Pco2 determination. J Appl Physiol 13: 515-520, 1958.

 

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Read the First Issues FREE!

American Journal of Physiology
American Journal of Physiology - Cell Physiology
American Journal of Physiology - Endocrinology and Metabolism
American Journal of Physiology - Gastrointestinal and Liver Physiology
American Journal of Physiology - Heart and Circulatory Physiology
American Journal of Physiology - Lung Cellular and Molecular Physiology
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology
American Journal of Physiology - Renal Physiology
Journal of Applied Physiology
Journal of Neurophysiology
Physiological Reviews
Advances in Physiology Education
Physiology
(previously News in Physiological Science)
Physiological Genomics

 

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